This user-friendly resource offers complete and comprehensive coverage of the difficult challenges of drug-drug interactions arise. More than 170 cases a variety of interactions (DDI) to show an unintimidating even entertaining way to understanding these issues. Drug interaction studies Primer builds on earlier work by the author, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features references throughout and 29 new cases that such clinical examples of how a patient with schizoaffective disorder transitions of haloperidol, aripiprazole diagnosed with offer devastating consequences, an AIDS patient with trimethoprim-sulfamethoxazole replace warfarin following atrial fibrillation, which returned to ischemic stroke, and a delusional patient on risperidone Phenytoin is used in these attacks, and delusions. Previous cases have been revised to provide clarity.
An introduction to key concepts, the brief reviews of each enzyme system comprises brings to the reader how to think about DDIs and begin with what may seem like an impressive fight on speed. The vignettes that follow each containing a case presentation and explanation of the mechanism by which the interaction occurred (s), and any results from good clinical evidence, not only projections of drug characteristics, provide a more realistic understanding of DDIs. Most of the described interactions involve the cytochrome P450 enzyme system, other changes included in the phase II metabolism and P-glycoprotein function, and plasma protein displacement effects. The annexes detail, most drug interactions between psychotropic substances and include metabolic pathways and inhibition and induction profiles for antidepressants, antipsychotics, and mood stabilizing agents, and tables that detail all known and clinically significant DDIs pairings between any two agents from these drug classes. A comprehensive index allows quick reference. Among other features of the book
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