Mountains for Mortals: New England: Scenic Summits for Hikers free ebook download

Although New England contains three of the four most densely populated states in the country, there are still numerous natural sites to be explored in this beautiful area, and this detailed guide catalogs the most unique and scenic mountains. From Mount Katahdin in Maine to the peaks above the coastline, the finest hikes are included here, along with beautiful photographs of the land and precise directions and descriptions.

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Fodor's California National Parks: Channel Islands, Death Valley, Joshua Tree, Lassen Volcanic, Redwood, Sequoia, Kings Canyon, Yosemite free ebook download

Get inspired and plan your next trip with Fodor’s e-book guide to California’s national parks: Channel Islands, Death Valley, Joshua Tree, Kings Canyon, Lassen, Sequoia, and Yosemite. To get your bearings, browse a brief overview of each park and peruse full-color maps of the region. You’ll develop an immediate sense of each park’s awe-inspiring landscape as you flip through an album of vivid full-color photographs. Read on and find all of the essential, up-to-date details you expect from a Fodor’s guide: From the best dining and lodging in the area to must-see hikes and scenic drives, Fodor’s has it all.

Discover seven great California parks in one e-book:
· Just 60 miles northwest of Los Angeles, the five islands of Channel Islands park are a nature-lover’s paradise and home to 145 species found nowhere else on the planet.
· Straddling the southern California and Nevada borders, Death Valley is the largest national park in the contiguous U.S. and features breathtaking vistas and blasting 120-degree heat.
· World-class rock climbing and spectacular desert scenery are highlights of Joshua Tree. The eponymous trees—twisted and prickly, with clumps of spiny leaves—are straight out of a Dr. Seuss book.
· Visitors to Lassen Volcanic will find spectacular geologic wonders plus more than 150 miles of hiking trails, countless mountain lakes and streams, and flowering meadows.
· Ancient evergreens tower over visitors among the jagged mountain slopes of Sequoia and Kings Canyon, which cover more than 850,000 acres combined.
· Shimmering waterfalls and the soaring granite monoliths of Half Dome and El Capitan are some of the classic images you’ll see in Yosemite’s 748,000 acres.

Note: This e-book edition includes photographs and maps that will appear on black-and-white devices but are optimized for devices that support full-color images.

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Estonia Latvia & Lithuania (Multi Country Guide) free ebook download

“Lands of crumbling castles, soaring dunes, pagan rituals, towering pine forests, quaking lakelands and churning northern seas – a trip to the Baltic proves that fairy tales do come true…” – Brandon Presser, Lonely Planet Writer

 Our Promise

 You can trust our travel information because Lonely Planet authors visit the places we write about, each and every edition. We never accept freebies for positive coverage so you can rely on us to tell it like it is.

 Inside This Book…

 5 expert authors

 3 months of research

 Hundreds of architectural gems

 Too many stuffed potato dumplings

 Outdoor Activities feature

 Clear, easy to use maps

 In-depth background

 At-a-glance practical info

 Comprehensive planning tools

 Easy-to-read layout

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Rome (City Travel Guide) free ebook download

“Walk around Rome and without even trying, you’ll stumble across masterpieces from the artistic pantheon – sculptures by Michelangelo, paintings by Caravaggio, frescoes by Raphael and fountains by Bernini.” – Duncan Garwood, Lonely Planet Writer

Our Promise

 You can trust our travel information because Lonely Planet authors visit the places we write about, each and every edition. We never accept freebies for positive coverage so you can rely on us to tell it like it is.

Inside This Book…

 2 expert authors

 5 Roman forums

 34 maps

 157 restaurants

 3000 years of art and architecture

 Comprehensive map section

 Feature coverage of top sights

 Range of planning tools

 In-depth background on Rome’s art and architecture

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The 101 Places Not to See Before You Die free ebook download

Because bad places make good stories 

 The Testicle Festival • Garbage City • Rush Hour on a Samoan Bus • Y our Boss's Bedroom • Ibiza on a Family Vacation • Stonehenge • The Road of Death • A North Korean Gulag • Fucking, Austria • And 92 More! 

 From the Grover Cleveland Service Area to the Beijing Museum of Tap Water to, of course, Euro Disney, 101 Places Not to See Before You Die brings you lively tales of the most ill-conceived museums, worst theme parks, and grossest Superfund sites that you'll ever have the pleasure of not visiting. Journalist Catherine Price travels the globe for stories of misadventure to which any seasoned traveler can relate—including guest entries from writers such as Nicholas Kristof, Mary Roach, Michael Pollan, Rebecca Solnit, and A. J. Jacobs—and along the way she discovers that the worst experiences are often the ones we'll never forget.

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Frommer's Seattle (Frommer's Color Complete) free ebook download

Full-color throughout
Free full-color, foldout map
Completely updated every year
Insider advice on everything from the best offbeat experiences in the Emerald City, to the best things to do on a rainy day.
Where to find the freshest seafood (DUCK when they throw that salmon at Pike Place Market!

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Frommer's Nova Scotia, New Brunswick and Prince Edward Island (Frommer's Complete Guides) free ebook download

Frommer's Nova Scotia, New Brunswick & Prince Edward Island is packed with all the facts, tips, and descriptions you need to have a perfect vacation
Our author has written about and lived in Atlantic Canada for years, so she's able to provide valuable insights and advice. She'll steer you away from the touristy and the inauthentic and show you the real heart of the Provinces.
Follow her picks for the best travel experiences   including sea-kayaking Nova Scotia, biking the Cabot Trail, hiking Gros Morne National Park, driving along the Viking Trail in Newfoundland, walking through Annapolis Royal in Nova Scotia, and feasting on fresh lobster and Digby scallops   and you're sure to have a fantastic trip.

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Frommer's Washington D.C. with Kids (Frommer's With Kids) free ebook download

nsider advice on the most fun and educational experiences for kids of all ages in the nation's capital. This completely updated edition is full of incredibly detailed tips - right down to which hotels offer cribs and rollaway beds and which restaurants offer high chairs and kids' menus.
Where to find hands-on, interactive museums  the best children's entertainment, from concerts and children's theater

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Eastern USA (Regional Guide) free ebook download

“Flanked by mega-cities New York City and Chicago  landscaped with dune-backed beaches, smoky mountains and gator swamps  and steeped in musical roots, the East rolls out a sweet trip.” – Karla Zimmerman, Lonely Planet Writer

 Our Promise

 You can trust our travel information because Lonely Planet authors visit the places we write about, each and every edition. We never accept freebies for positive coverage so you can rely on us to tell it like it is.

 This book includes…

 Massachusetts, Rhode Island, Connecticut, Vermont, New Hampshire, Maine, Washington DC, Maryland, Delaware, Virginia, West Virginia, New York, New Jersey, Pennsylvania, North Carolina, South Carolina, Georgia, Alabama, Mississippi, Louisiana, Arkansas, Tennessee, Florida, Illinois, Indiana, Ohio, Michigan, Wisconsin and Minnesota.

 Inspirational photos
 Clear, easy-to-use maps
 Road Trips & Scenic Drives
 In-depth background

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Fodor's Antigua & Montserrat (Fodor's eBooks) free ebook download

Get inspired and plan your next trip with Fodor’s ebook travel guide to Antigua and Montserrat. Easy navigation makes it simple for you to move through each section of the ebook with a simple touch. To get your bearings, browse a brief overview and peruse full-color maps of the islands. You’ll immediately develop a sense of each island’s awe-inspiring beauty as you flip through a vivid full-color photo album. Read more about the islands and find all of the essential, up-to-date details you expect in a Fodor’s guide: From the best dining and lodging to top beaches and attractions, Fodor’s has it all.

Discover three great Caribbean islands in one ebook. At 108 square miles, Antigua is the largest of the British Leeward Islands and with its sister island Barbuda comprises 365 excellent beaches, one for every day of the year. Although the Soufriere Hills volcano continues to rumble in Montserrat, the island is otherwise as peaceful as the Caribbean gets—almost a throwback to another time, with the occasional modern convenience thrown in.

Fodor’s helps you unleash the possibilities of travel with the insightful tools you need to experience the trips you want. Plan your ideal trip armed with the assurance of our expertise, the guarantee of selectivity, and the choice details that define a destination.

Note: This ebook edition includes photographs and maps that will appear on black-and-white devices but are optimized for devices that support full-color images.

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Washington DC (City Guide) free ebook download

“Climb the steps of the Lincoln Memorial, stare into Abe’s stony eyes and read his Gettysburg Address chiseled in the wall. Stand where Martin Luther King Jr gave his famous speech and feel the sweep of history.” – Karla Zimmerman, Lonely Planet Writer

Our Promise
You can trust our travel information because Lonely Planet authors visit the places we write about, each and every edition. We never accept freebies for positive coverage so you can rely on us to tell it like it is.

Inside This Book…
Full color guide
Free pull-out city map
87 bars, lounges and clubs
35 pages of family-friendly attractions
24 free museums
3 miles of lawn on the National Mall
1 big, white house
Comprehensive map section
DC for Families Planning feature
Range of planning tools
In-depth coverage of top sights

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Great Victorian Railway Journeys: How Modern Britain Was Built by Victorian Steam Power free ebook download

The perfect companion to Bradshaw's guide book. Showcasing in colour all that is great about Bradshaw's guide. Great British Railway Journeys has been a hugely successful TV programme, which is now into its third series on BBC2. Much as Michael Palin built up a dedicated fan base for travel around the globe, so Michael Portillo has done likewise for lovers of trains in his explorations the length and breadth of the United Kingdom from the window of a train seat. Both charming and insightful, Michael again uses Bradshaw's guides, and now undertakes five unique journeys that were constructed by the Victorians from 1830-1900. Across 25 episodes he delves into this fascinating and colourful period of our history, and show how the modern British landscape was created from this Victorian legacy. From Windsor to Weymouth, Great Yarmouth to London, Oxford to Milford Haven, Berwick to Barrow, and finally Dublin to Belfast - Michael will go back in time to showcase areas of outstanding Victorian engineering and design across Queen Victoria's dominions. Key parts of the programme and tie-in book will showcase how the world's very first fixed-track train in Merthyr Tydfil operated  how the world's first electric train service ran in Southend to its famous pier  and he also celebrates the wide variety of lines that opened up trade and mobility to the Victorian classes. Travelling on a variety of existing, and in some cases restored, Victorian train lines, he meets their passionate supporters who lovingly work on them, and also looks at the modern landscape to tell the story of how each area was shaped by their Victorian forebears. Lavishly produced, this will once again be a 'must have' purchase for all train lovers, as well as those who simply want to find out their heritage and what is now available to view and travel upon in the 21st century to transport them back in time.

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The Role of Model Integration in Complex Systems Modelling: An Example from Cancer Biology free ebook download

Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

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Colorectal Cancer free ebook download

Colorectal cancer is the second most common cause of cancer death in the developed world. The last five years have seen dramatic improvements in the multidisciplinary management of this malignancy. In this volume, experts at the forefront of these advances contribute their knowledge and experience on the major advances that have occurred in diagnosis, staging, preoperative and adjuvant therapy, surgery and follow-up assessment of patients with this disease. Imaging underpins all aspects of the clinical management of colorectal cancer and has been shown to play a critical role in improving outcomes for patients. About the series Each volume in Contemporary Issues in Cancer Imaging - A Multidisciplinary Approach is edited by an expert guest editor, with contributions from all members of the multidisciplinary team, bringing together expertise from many specialties to promote the understanding and application of modern imaging in overall patient management.

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100 Questions and Answers About Cancer Symptoms and Cancer Treatment Side Effects, Second Edition free ebook download

100 Questions & Answers About Cancer Symptoms and Cancer Treatment Side Effects, Second Edition provides authoritative answers to the most commonly asked questions about cancer symptoms and treatments. Written by cancer professionals and featuring comments from actual patients, this handy guide gives you the information you need to understand the disease and manage treatment side effects. This completely revised and updated version includes topics on cancer treatment options such as surgeries, targeted therapy, biologic therapies, alternative treatments; sexuality, fertility, pregnancy issues, pain and fatigue management, and more! Accessible, informative, compact, 100 Questions & Answers About Cancer Symptoms and Cancer Treatment Side Effects, Second Edition is a unique resource for anyone coping with the physical and emotion turmoil of cancer.

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Insertional Mutagenesis Strategies in Cancer Genetics free ebook download

The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials. 

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Physical Activity, Dietary Calorie Restriction, and Cancer (Energy Balance and Cancer, Vol. 3)Dietary free ebook download

The World Health Organization estimates that 25 percent of common cancers can be prevented through regular physical activity and weight control. Common cancers linked to overweight/obesity and a sedentary lifestyle include breast, colon, endometrium, pancreas, renal, esophageal, and several others. There are several plausible mechanisms linking lack of physical activity and increased adiposity to cancer risk, supported by results from animal experiments and human intervention studies. 

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Thyroid Cancer in Clinical Practice free ebook download

The book covers all aspects of thyroid cancer, including nodules, pathology, thyroid and whole-body scans, ultrasounds, and other nuclear medicine and radiological studies, as well as follow-up testing and prognosis. It tackles the treatment of differentiated thyroid cancer (the commonest variety) and all aspects of the management including surgery, the role and logistics of radioactive iodine and long-term prescription of thyroid hormone. Also included are images and up to-date procedures such as fused Positron Emission Tomography/Computed Tomography (PET/CT) images.

A pocket-sized easily accessible source of information to supplement existing large texts, this book provides a handy reference for everyday use for physicians, including primary care doctors, practitioners and trainees in endocrinology, nuclear medicine, oncology, surgery, otolaryngology, radiation and medical oncology, and internal medicine. It will also be a resource for residents, medical students, nurse practitioners, and patients.

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Cancer Cytogenetics, 3 Edition free ebook download

The preeminent book on cancer cytogenetics—now in a valuable new edition

Like its successful predecessors, Cancer Cytogenetics, Third Edition continues to offer authoritative coverage of neoplastic processes at the chromosomal level of genomic organization. Now updated and expanded, this new edition includes detailed information on the most recent advances in the field, incorporating a vast amount of new cytogenetic as well as molecular genetic data from the latest basic and clinical investigations.

Edited by two leading authorities, who are now aided by a panel of internationalexperts, this new edition has been updated to include:

* Greatly expanded coverage of solid tumors

*Enhanced coverage of acute and chronic myeloproliferative disorders

*The latest findings on acute and chronic lymphoproliferative disorders

Cancer Cytogenetics, Third Edition is a valuable resource for researchers in a wide range of fields, including cytogenetics, medical and molecular genetics, cellular and molecular biology, oncology, and hematology. With its complete coverage of thecytogenetic mechanisms underlying neoplasia, and always with a keen eye on the clinical consequences of the various acquired genetic aberrations, this text will alsobe an indispensable reference for all clinicians involved in the diagnosis and treatment of cancer patients. 

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Imaging of Kidney Cancer (Medical Radiology / Diagnostic Imaging) free ebook download

This is one of the first books to deal specifically with diagnostic imaging of the entire spectrum of kidney cancers. Both new and conventional imaging modalities are fully considered. After an introductory chapter on the histopathological classification of kidney cancers, the advantages and disadvantages of the various imaging modalities used in the diagnosis and assessment of disease extension are documented. Subsequent chapters offer an exhaustive description of the radiological features of the different histological subtypes of kidney cancer 

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Methods of Cancer Diagnosis, Therapy, and Prognosis: Brain Cancer free ebook download

 Methods of Cancer Diagnosis, Therapy, and Prognosis: Brain Cancer (Methods of Cancer Diagnosis, Therapy and Prognosis, Volume 8)

This eighth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses in detail the classification of the CNS tumors as well as brain tumor imaging. Scientists and Clinicians have contributed state of the art chapters on their respective areas of expertise, providing the reader a whole field view of the CNS tumors and brain tumor imaging in Europe. This fully illustrated volume: Explains the genetics of malignant brain tumors and gene amplification using quantitative-PCR; Presents a large number of standard and new imaging modalities, including magnetic resonance imaging, functional magnetic resonance imaging, diffusion tensor imaging, amide proton transfer imaging, positron emission tomography, single photon emission computed tomography, magnetic resonance single voxel spectroscopy and intraoperative ultrasound imaging, for staging and diagnosing various primary and secondary brain cancers; Explains the usefulness of imaging methods for planning and monitoring (assessment) therapy for cancers; Discusses diagnosis and treatment of primary CNS lymphomas, CNS atypical teratoid/rhabdoid and CNS Rosai-Dorfman disease; Includes the subject of translational medicine.

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100 Questions & Answers About Bladder Cancer, Second Edition free ebook download

Product Description: Whether you're a newly diagnosed bladder cancer patient, a survivor, or a friend or relative of either, this book offers help. The completely updated and revised 100 Questions & Answers About Bladder Cancer, Second Edition gives you authoritative, practical answers to your questions about current treatment options, post-treatment quality of life, coping strategies, sources of support, and much more. Written by a prominent urologist, with "insider" advice from actual patients, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

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Cancer: A Comprehensive Clinical Guide free ebook download

Product Description: An understanding of the basic mechanisms and management of cancer has become essential knowledge for medical students and doctors. Cancer: A Comprehensive Clinical Guide explains the principles and practice of oncology in a clear and easy-to-read format, combining the latest in research and treatment with an informed description of the underlying biology.

The editors have adopted a multidisciplinary approach which successfully integrates the medical and nursing aspects of cancer care. An introductory section, discussing general principles and aspects of oncology, is followed by site-specific chapters describing the epidemiology, pathology, clinical signs, investigations, diagnosis, and treatment of each cancer type. Special chapters are devoted to cancer in children, HIV-associated malignancies, secondary cancers, and unknown primary cancers.

This informative book highlights current trends in the diagnosis and treatment of all cancers, including aspects of nursing and palliative care. 

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Tumor Suppressing Viruses, Genes, and Drugs: Innovative Cancer Therapy Approaches free ebook download

Product Description: Tumor Suppressing Viruses, Genes, and Drugs profiles the new generation of cancer treatments now in development. The book examines the innovative new approaches of viral, gene, and signal therapies that promise to replace or enhance conventional methods such as surgery, radiation, and chemotherapy. The timely information presented by this book should be of interest to anyone concerned with advancing cancer treatment beyond current medical practices.

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Tropic of Cancer free ebook download

Now hailed as an American classic, Tropic of Cancer, Henry Miller’s masterpiece, was banned as obscene in this country for twenty-seven years after its first publication in Paris in 1934. Only a historic court ruling that changed American censorship standards, ushering in a new era of freedom and frankness in modern literature, permitted the publication of this first volume of Miller’s famed mixture of memoir and fiction, which chronicles with unapologetic gusto the bawdy adventures of a young expatriate writer, his friends, and the characters they meet in Paris in the 1930s. Tropic of Cancer is now considered, as Norman Mailer said, ?one of the ten or twenty great novels of our century.”

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Atlas of Staging in Gynecological Cancer free ebook download

"Atlas of Staging in Gynecological Cancer" is designed to be used in conjunction with diagnostic procedures between the surgeon and the radiologist. It describes the two common staging regimes used by all units across the world, namely, the FIGO staging system and the TNM system. The ‘landscape’ format allows each chapter to open on the left hand side and read across the double spread, enabling the reader to see both staging systems at once. Each chapter has a separate section on Epidemiology, Diagnosis, with radiological plates, Management, in tabular form, and Key Points.

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Cancer Biology free ebook download

Product Description: The fourth edition of this classic text provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It defines the fundamental pathophysiologic changes that occur in tumor tissue and in the host animal or patient. Each chapter discusses the historical development of a field, citing the key experimental advances to the present day, and evaluates the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well written and well illustrated, with schematic diagrams and actual research data to demonstrate points made in the text. There is also an extensive, up-to-date bibliography, making the book valuable to scientists, and to physicians, students, and nurses interested in the field of cancer biology. The topics covered include pathologic characterization of human tumors, epidemiology of human cancer, regulation of cell proliferation and differentiation, cellular and molecular phenotypic characteristics of the cancer cell, mechanisms of carcinogenesis, tumor initiation and promotion, viral carcinogenesis, oncogenes and oncogene products, growth factors, chromosomal alterations in cancer, mechanisms of tumor metastasis, host-tumor interactions, fundamental aspects of tumor immunology, and the advances in cancer cell biology that will lead to improved diagnosis and treatment of cancer in the future.

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Breast Cancer: A Lobar Disease free ebook download

Product Description: The theory of the sick lobe states that breast carcinoma is a lobar disease developing most often within a single lobe, meaning that, at an early stage, breast carcinoma occupies a limited, anatomically well-defined portion of the breast. This theory unites observed patterns from the genetic, developmental and morphological perspectives, into an overall concept. Breast Cancer: A Lobar Disease, presents this hypothesis and its consequences. The body of evidence, pro and contra, generated in recent years will be presented in this volume. The chapters, all authored by leading experts in their respective areas, gather evidence from the perspectives of epidemiology, genetics, radiology, anatomy, developmental biology, morphology, endoscopy, ultrasound and therapeutics to give the reader a full picture of recent developments regarding the sick lobe hypothesis. Tibor Tot, MD PhD is Head of the Pathology and Clinical Cytology Department at the Central Hospital of Falun, in Sweden; breast cancer expert of the National Board of Health and Welfare in Sweden; and regular Course Director of the breast pathology program, the official educational program for Swedish residents in clinical pathology, oncology, radiology and surgery.

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Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice free ebook download

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. 

In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

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Tumors of the Brain and Spine (M.D. Anderson Cancer Care Series) free ebook download

Tumors of the Brain and Spine focuses primarily on approaches to the treatment of benign, primary low-grade to high-grade, and metastatic tumors in the brain and spine, as practiced by surgeons and clinicians at the University of Texas M. D. Anderson Cancer Center. The book is written mainly for the primary care oncologist, general neurologist, and general neurosurgeon. Discussion of treatment coverage focuses on neurosurgery, chemotherapy, and radiation therapy, singly and in combination. Also included are chapters on symptom management, molecular genetics and neuropathology of intracranial tumors, leptomeningeal dissemination of systemic cancer, epidemiology of brain tumors, and innovative treatment strategies.

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Cancer Cell Culture: Methods and Protocols (Methods in Molecular Medicine) free ebook download

Expert researchers describe in detail their most productive and up-to-date methods for growing cancer cells in the laboratory. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided to evaluate clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Other methods permit the modification of cancer cells for transfection, development of drug resistance, immortalization, and transfer in vivo; the co-culture of different cell types; and the detection and treatment of contamination.

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Cancer in Adolescents and Young Adults (Pediatric Oncology) free ebook download

This is the first comprehensive book devoted exclusively to cancer in adolescents and young adults. It compiles medical, epidemiological, biological, psychological, and emotional issues of young adults’ oncology. The emphasis is on the differences of the "same" cancer in younger and older patients. Model programs specially designed to care for patients in the age group and surveillance of long-term adverse effects are reviewed. 

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Management of Breast Cancer in Older Women free ebook download

There has been a recent surge of interest in the general topic of how older patients should be treated with various forms of malignancy, with particular focus on the management of breast cancer. This group of patients has been neglected in the past, with a failure to recruit them to clinical trials resulting in a lack of evidence on which to base treatment guidelines. The co-editors on this title are directly involved in a number of initiatives to address this gap in knowledge, and are thus perfectly placed to invite other expert individuals to author specific chapters in the proposed text.

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Prostate Cancer (Recent Results in Cancer Research) free ebook download

This comprehensive and easy-to-read monograph is an authoritative update on clinical prostate cancer. It has been prepared by an international, multidisciplinary team at the invitation of the International Prostate Health Council think tank. A particular strength of the book is its presentation of the therapeutic options for patients with localized and advanced disease, including hormonal treatment.

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Breast Cancer Risk Reduction and Early Detection free ebook download

The purpose of Breast Cancer Risk Reduction and Early Detection is to provide a single source for primary care physicians, nurses and the lay community to obtain the current approach to breast cancer prevention and early detection. The chapters will be written by experts in the field and will address current science, future directions, and questions that individuals might have to regarding their options to minimize their breast cancer risk, and to find disease that is present as soon as possible.

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Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention (Diet and Cancer) free ebook download

Product Description: Vegetables, Whole Grains and their Derivatives in Cancer Prevention looks in detail at the evidence regarding the effects and mechanisms of action of potentially cancer-preventive components and their sources from plant kingdom. The book covers current knowledge on certain foods and their constituents in cancer prevention, such as cruciferous and green leafy vegetables, nuts and seeds, whole grains, tomato lycopene and carotenoids, alliums and their sulphur and selenium constituents, and capsaicinoids from chilli peppers. It focuses not only on single compounds but aims to widen the view by discussing a whole-diet approach in cancer prevention. A single component may lose its chemopreventive efficacy when isolated from the food matrix and in many cases isolated and concentrated components as supplements may actually induce tumor development. Apart from describing the effects and mechanisms of action, the chapters also contain information on intake, bioavailability, metabolism and possible toxic effects of foods and components presented. Evaluation and comparison of the data from mechanistic studies in vitro with those from animal experiments in vivo form a basis for applying the current knowledge to human nutrition in the field of carcinogenesis. With contributions from leading experts in the field, this book is an invaluable resource for scientists and professionals working in cancer research, as well as individuals involved in food and nutrition.

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Outcomes Assessment in Cancer: Measures, Methods and Applications free ebook download

Product Description: The U.S. National Cancer Institute established the Cancer Outcomes Measurement Working Group in 2001 to evaluate measurements of the important and diverse impacts of cancer on individuals and populations. The findings and recommendations of the working group's 35 internationally recognized members provide alternative approaches for comprehensively measuring the burden of cancer and the effectiveness of preventive and therapeutic interventions.

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Autologous And Cancer Stem Cell Gene Therapy (Progress in Gene Therapy) free ebook download

Product Description: Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients. 

 This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy. 

 Contents: Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy; Long-term Stem Cell Gene Therapy: From Current Clinical Random-Integration Achievements to Stem Cell Gene Targeting/Cybridization: From Pioneering Clinical Retroviral Gene Therapy to Experimental Site-Specific Integrative Gene Therapy; Stem Cell Gene Targeting/Cybridization: Toward Endonuclease-Boosted Gene Repair/Alteration, Custom Site-Specific Integrative Gene Therapy and Transmitochondrial Therapy/Rejuvenation; Adult Pluripotent Stem Cells: Emerging Stem Cell/Gene Therapy Breakthrough; Cancer Stem Cell Gene Therapy: Cancer Stem Cells as Breakthrough Targets of Cancer Gene Therapy; Armed Stem Cells as Tumor-Homing Vectors for Cancer Gene Therapy.

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Gene Therapy of Cancer: Methods and Protocols (Methods in Molecular Biology) free ebook download

Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data. "Gene Therapy of Cancer: Methods and Protocols, Second Edition" fully updates the first edition with expert coverage of established and novel protocols involving both experimental and clinical approaches to cancer gene therapy. This state-of-the-art volume contains overviews of new concepts and strategies with chapters on regulatory and ethical issues, developments, problems and possible limitations of design and production of gene therapeutics as well as translational issues. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. 

Cutting edge and authoritative, "Gene Therapy of Cancer: Methods and Protocols, Second Edition" is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy.

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Skin Cancer - A World-Wide Perspective free ebook download

Product Description: Over the last decades the incidence of skin cancers is dramatically increasing world-wide. This is not only confined to the incidence of melanoma but includes also other skin cancers such as basal cell carcinomas. Based on the recent WHO classification of skin cancers, this lavishly illustrated reference book covers comprehensively the epidemiology, histology and pathology, as well as diagnostic signs and treatment options of skin cancers. Homogenously and reader-friendly structured, it links the diagnostic and genetic features of each disease in order to guide the reader to the most appropriate therapeutic strategies for the best possible treatment outcome. In order to demonstrate the world wide activities in the field, all chapters cover the variations of the individual experiences and expertise in different nations.

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Cancer Genome and Tumor Microenvironment (Cancer Genetics) free ebook download

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are "soft-wired", i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

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Methods of Cancer Diagnosis, Therapy, and Prognosis: Ovarian Cancer, Renal Cancer, Urogenitary tract Cancer, Urinary Bladder Cancer, Cervical Uterine ... Leukemia, Multiple Myeloma and Sarcoma free ebook download

This sixth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses Ovarian Cancer, Renal Cancer, Urogenitary Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma. Both standard and emerging therapies for these cancers, written by expert oncologists/pathologists in this field, are included. 

This fully illustrated volume  

 * Identifies biomarkers based on genetic alterations for clear cell ovarian adenocarcinoma. 

 * Identifies subgroups of ovarian cancer by using differential gene expression. 

 * Includes the application of the power-Doppler imaging for distinguishing benign from malignant complex adrenal masses in ovarian cancer. 

 * Emphasizes the advantage of using cytoreduction surgery for diagnosing advanced ovarian cancer. 

 * Provides details on the treatment of kidney cancer with radiofrequency ablation, surgery, and chemotherapy. 

 * Explains the use of immunohistochemistry for diagnosing adenomatoid tumor of the adrenal gland. 

 * Discusses the chemotherapy of testicular cancer and related second primary tumors. 

 * Includes the diagnosis of urothelial bladder cancer with urine-based tumor markers. 

 * Explains the use of immunohistochemistry and MRI for diagnosing uterine cervical cancer and describes the staging of this cancer using PET alone or PET/CT. 

 * Describes the localization of malignant melanoma using FDG-PET/CT. 

 * Explains the use of prognostic receptors for nonmelanoma skin cancer. 

 * Details the treatment of multiple myeloma using immunotherapy, radiotherapy, and targeted radionuclide therapy. 

 * Presents diagnostic immunohistochemistry of synovial and Kaposi's sarcoma. 

The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of these different types of cancer. 

Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

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With Liberty and Justice for Some: How the Law Is Used to Destroy Equality and Protect the Powerful free ebook download

From "the most important voice to have entered the political discourse in years" (Bill Moyers), a scathing critique of the two-tiered system of justice that has emerged in America

From the nation's beginnings, the law was to be the great equalizer in American life, the guarantor of a common set of rules for all. But over the past four decades, the principle of equality before the law has been effectively abolished. Instead, a two-tiered system of justice ensures that the country's political and financial class is virtually immune from prosecution, licensed to act without restraint, while the politically powerless are imprisoned with greater ease and in greater numbers than in any other country in the world.

Starting with Watergate, continuing on through the Iran-Contra scandal, and culminating with Obama's shielding of Bush-era officials from prosecution, Glenn Greenwald lays bare the mechanisms that have come to shield the elite from accountability. He shows how the media, both political parties, and the courts have abetted a process that has produced torture, war crimes, domestic spying, and financial fraud.

Cogent, sharp, and urgent, this is a no-holds-barred indictment of a profoundly un-American system that sanctions immunity at the top and mercilessness for everyone else.

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Health Care Law free ebook download

Health Care Law provides essential information necessary for students pursuing careers in the growing health care sector, as paralegals, managers, or compliance/ethics professionals. This text offers students easy-to-read chapters that provide outlines, learning objectives, summaries, and exercises to assist students with comprehension. Chapters focus on key information such as the types of health care entities, and the laws and ethics that govern them, and discuss the major areas of health care law, including regulatory research and administrative law review. Also highlighted are important contemporary topics like electronic health records, corporate compliance, HIPAA privacy and security, physician professional relationships, and prepares students for their careers with real-world examples.

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Electronic Legal Research: An Integrated Approach free ebook download

Electronic Legal Research: An Integrated Approach, second edition, is dedicated to fully explaining the rationale of legal research, guiding readers through the individual steps necessary to develop their own research strategies. Through exploration into the topic of legal database searching with substance and depth, Electronic Legal Research facilitates long-term learning. Since new products are introduced every day and the market leaders constantly change, this text takes the approach of one set of skills, Boolean searching. This approach will enable the beginning researcher to do research in nearly any electronic database, specifically training students to research paid legal databases and the Internet. Electronic Legal Research: An In

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Delinquency in Society:: Youth Crime in the 21st Century free ebook download

This conversational text makes delinquency interesting to read about. Delinquency in Society provides a critical look at a very serious problem through a clear and thorough presentation of the theories of delinquency. In accessible, student-friendly language the authors prepare their readers to understand all facets of delinquency, including the history, institutional context, and societal reactions to delinquent behavior, the major biological, psychological, and sociological theories of behavior, and the variety of policy implications derived from those theories.

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Explaining Criminals and Crime: Essays in Contemporary Criminological Theory free ebook download

Explaining Criminals and Crime is the first collection of original essays addressing theories of criminal behavior that is written at a level appropriate for undergraduate students. These clear, concise, accessible essays were written expressly for this book, either by the original author(s) of each theory or by a scholar who has written extensively about it.

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Cyber Criminology: Exploring Internet Crimes and Criminal Behavior free ebook download

Victimization through the Internet is becoming more prevalent as cyber criminals have developed more effective ways to remain anonymous. And as more personal information than ever is stored on networked computers, even the occasional or non-user is at risk. A collection of contributions from worldwide experts and emerging researchers, Cyber Criminology: Exploring Internet Crimes and Criminal Behavior explores today’s interface of computer science, Internet science, and criminology.

 Topics discussed include:

 The growing menace of cyber crime in Nigeria

 Internet gambling and digital piracy

 Sexual addiction on the Internet, child pornography, and online exploitation of children

 Terrorist use of the Internet

 Cyber stalking and cyber bullying

 The victimization of women on social networking websites

 Malware victimization and hacking

 The Islamic world in cyberspace and the propagation of Islamic ideology via the Internet

 Human rights concerns that the digital age has created

 Approaching the topic from a social science perspective, the book explores methods for determining the causes of computer crime victimization by examining an individual’s lifestyle patterns. It also publishes the findings of a study conducted on college students about online victimization.

 Advances in information and communications technologies have created a range of new crime problems that did not exist two decades ago. Opportunities for various criminal activities to pervade the Internet have led to the growth and development of cyber criminology as a distinct discipline within the criminology framework. This volume explores all aspects of this nascent field and provides a window on the future of Internet crimes and theories behind their origins.

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DeathQuest, Third Edition: An Introduction to the Theory and Practice of Capital Punishment in the United States free ebook download

The first true textbook on the death penalty, this text provides an exhaustive introduction, starting with its history and taking the reader through the facts, issues, opinions and controversies surrounding capital punishment. The author's motivation has been to understand what motivates the "deathquest" of the American people, leading a large percentage of the public to support the death penalty. The book will educate readers so that whatever their death penalty opinions are, they are informed ones.

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Criminal Justice in Action free ebook download

The Sixth Edition of CRIMINAL JUSTICE IN ACTION places you in the center of the action and helps you excel in your criminal justice course! You'll explore vivid real-life applications that clarify key criminal justice concepts and read about the many exciting new career opportunities that the field now offers. Concepts will suddenly make sense thanks to this editi

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